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- Title
Am I my brother's keeper?: fratricide in the kidney.
- Authors
Safirstein, Robert L.
- Abstract
Experimental acute kidney injury (AKI) is accompanied by the death of renal tubule epithelial cells, necrosis and apoptosis of the terminal portion of the proximal tubule, and apoptosis in the distal nephron. While immune competent cells invading the kidney play a role in such cell death, intervention in these processes only partially ameliorates the extent of cell death. Given the results of Linkermann et al. in this issue of KI, an epithelium-derived component of immune mediated cell death must now be strongly considered.
- Subjects
FRATRICIDE; EPITHELIAL cells; APOPTOSIS; KIDNEY tubules; CELL death
- Publication
Kidney International, 2011, Vol 79, Issue 2, p149
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2010.441