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- Title
Inflammatory bowel disease and preterm delivery
- Authors
Elbaz, Gabby; Fich, Alex; Levy, Amalia; Holcberg, Gershon; Sheiner, Eyal
- Abstract
Abstract: Objective: The present study investigates pregnancy outcome in women with IBD and examines the effect of pregnancy on the severity of IBD. Method: A case-control study comparing deliveries by mothers with IBD between January 1988 and January 2005 was performed. For every birth by a mother with IBD, four births by non-IBD mothers were randomly selected and adjusted for ethnicity and year of delivery. Result: During the study period there were 48 deliveries to patients with Crohn''s disease and 79 deliveries to patients with ulcerative colitis. Higher rates of preterm delivery (<37 weeks) were found among patients with IBD as compared to the controls (odds ratios (OR)=2.2; 95% confidence interval (CI)=1.3–3.8). This association remained significant after adjustment for labor induction and multiple gestations, using the Mantel–Haenszel technique (weighted OR=2.1; 95% CI 1.3–3.5 and weighted OR=2.0; 95% CI 1.2–3.5; P =0.012; respectively). In addition, these patients had higher rates of fertility treatments (OR=2.2; 95% CI=1.1–4.4). Using a multivariate analysis, controlling for maternal age and fertility treatments, preterm delivery was seen to be significantly associated with IBD (adjusted OR=2.0; 95% CI=1.2–3.5). Perinatal outcomes, such as perinatal mortality, low Apgar scores, and congenital malformations, were comparable to the outcomes in the control group. Conclusion: Maternal IBD is an independent risk factor for preterm delivery. IBD is not associated with adverse perinatal outcome.
- Subjects
ISRAEL; INFLAMMATORY bowel diseases; ULCERATIVE colitis; COLON diseases; PREGNANCY; PREMATURE labor; EVALUATION of medical care; PREGNANCY complications; CASE-control method
- Publication
International Journal of Gynecology & Obstetrics, 2005, Vol 90, Issue 3, p193
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2005.06.003