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- Title
The design and protocol of acupuncture for migraine prophylaxis: A multicenter randomized controlled trial.
- Authors
Yan Zhang; Linpeng Wang; Huilin Liu; Nan Li; Jingdao Li; Jinghong Yi
- Abstract
Background: Many studies have already reported encouraging results in the prophylactic therapy of migraine by acupuncture, but there seems to be a lack of high quality randomized controlled trials from China. We design and perform a randomized controlled clinical trial to evaluate the efficacy of acupuncture compared with flunarizine in the prophylactic therapy of patients with migraine without aura in China. Methods: This trial is a multicenter, prospective, randomized controlled clinical trial. The 140 migraine patients are randomly allocated to two different groups. The acupuncture groups (n = 70) is treated with acupuncture and placebo medicine; while the control group (n = 70) is treated with sham acupuncture and medicine (Flunarizine). Both Flunarizine and placebo are taken 10 mg once per night for the first 2 weeks and then 5 mg once per night for the next 2 weeks. Patients in both groups receive 12 sessions of verum/sham acupuncture in 4 weeks. Discussion: The study design and the long term clinical practice of acupuncturists guarantee a high external validity for the results. The results of our trial will be helpful to supply the evidence on the efficacy of acupuncture for migraine prophylaxis in China. Trial Registration: The trial is registered at Controlled Clinical Trials: ISRCTN49839714.
- Subjects
CHINA; ACUPUNCTURE; RANDOMIZED controlled trials; MEDICAL research; THERAPEUTICS; DRUG efficacy
- Publication
Trials, 2009, Vol 10, p1
- ISSN
1745-6215
- Publication type
Article
- DOI
10.1186/1745-6215-10-25