We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Isolation of an antimicrobial racemic phenalenone derivative from a marine-derived Penicillium sp. fungus.
- Authors
Morehouse, Nicholas J.; Graham, Kelsie M.; Cox, Samantha L.; Johnson, John A.; Gray, Christopher A.
- Abstract
A new phenalenone derivative, 2,4,6,9-tetrahydroxy-7-methyl-2-prenyl-1H-phenalene-1,3(2H)-dione (1), was isolated from the ethyl acetate extract of a marine-derived Penicillium sp. fungus that exhibited a unique antimicrobial activity profile. The planar structure of 1 was determined through a combination of 1D and 2D NMR experiments, and circular dichroism and polarimetry indicated that it was isolated as a racemic mixture of enantiomers. The antimicrobial activity of 1 was assessed against a panel of gram-positive and gram-negative bacteria and fungal strains, and it was found to selectively inhibit the growth of Staphylococcus aureus and Mycobacterium tuberculosis.
- Subjects
PENICILLIUM; RACEMIC mixtures; GRAM-positive bacteria; GRAM-negative bacteria; MYCOBACTERIUM tuberculosis; ETHYL acetate
- Publication
Canadian Journal of Chemistry, 2024, Vol 102, Issue 3, p86
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2023-0100