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- Title
Tetanus antibodies in normal human immunoglobulin preparations.
- Authors
Farcet, Maria R.; Lackner, Cornelia; Schirmer, Andreas; Kreil, Thomas R.
- Abstract
With respect to PEP of tetanus, 10-20 mL of 10% IGI should suffice to administer the recommended 250-500 IU of tetanus antibody, assuming the lowest tetanus potency that was determined, that is, 26.0 IU/mL (Table 1). In conclusion, we provide comprehensive evidence that current 10% IGI preparations consistently contain tetanus antibodies at levels that allow for tetanus PEP as well as tetanus therapy, with negligible lot-to-lot variability. When tetanus toxin antibody concentrations of 39 lots of 13 different commercial IGI products of six different manufacturers [[4]] were normalized for protein content, a mean potency of 30.5 ± 2.5 IU/mL was calculated (Table 1), very similar to the antibody concentration determined in the current IGI, 10% preparations.
- Subjects
TETANUS; IMMUNOGLOBULINS; TETANUS toxin
- Publication
Vox Sanguinis, 2023, Vol 118, Issue 10, p906
- ISSN
0042-9007
- Publication type
Article
- DOI
10.1111/vox.13506