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- Title
Apparent Lack of Gene Dosage Effect in the PLT Assay.
- Authors
Jaramillo, S.; Anhorn, G.; Schunter, F.; Wernet, P.
- Abstract
in this paper the results of primed lymphocyte typing (PLT) tests are reported which show the response to HLA-D-specific stimulator and to unrelated cells. The aim was to find out the sensitivity of the PLT method for evaluating not only qualitative HLA-D-region differences but also gene dosage effects. in addition, the primed cells were restimulated with cells from HLA-D-homozygous individuals mutually negative with the specific stimulator in the usual 5-day primary mixed lymphocyte culture incubation. No gene dosage effect in PLT experiments could be observed.
- Subjects
LYMPHOCYTES; B cells; CELLS; GENES; CELL culture; MOLECULAR genetics
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 5, p529
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb02116.x