We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Salivary microbiota and inflammation‐related proteins in patients with psoriasis.
- Authors
Belstrøm, Daniel; Eiberg, Josefine Maria; Enevold, Christian; Grande, Maria Anastasia; Jensen, Claus Antonio Juel; Skov, Lone; Hansen, Peter Riis
- Abstract
Objective: The purpose of the present study was to characterize the composition of the salivary microbiota and quantify salivary levels of inflammation‐related proteins (neutrophil gelatinase‐associated lipocalin [NGAL] and transferrin) in patients with psoriasis and compare data to those obtained in patients with periodontitis and orally healthy controls, respectively. Materials and methods: Stimulated saliva samples from patients with psoriasis (n = 27), patients with periodontitis (n = 58), and orally healthy controls (n = 52) were characterized by means of next‐generation sequencing of the 16S rRNA gene. Salivary levels of NGAL and transferrin were quantified using immunoassays. Results: Linear discriminant effect size analysis showed that 52 (22 psoriasis‐associated and 30 periodontitis‐associated) and 21 (8 psoriasis‐associated and 13 orally healthy control‐associated) bacterial taxa differentiated the salivary microbiota in patients with psoriasis from that of patients with periodontitis and orally healthy controls, respectively. Significantly lower mean salivary levels of NGAL (psoriasis: 996 [std. error 320], periodontitis: 2,072 [295], orally healthy controls: 2,551 [345] ng/ml, p <.0001) and transferrin (psoriasis: 4.37 [0.92], periodontitis: 7.25 [0.88], orally healthy controls: 10.02 [0.94] ng/ml, p <.0001) were identified in patients with psoriasis. Conclusions: Psoriasis associates with characteristics of the salivary microbiota and salivary levels of inflammation‐related proteins, which are different from characteristics in patients with periodontitis and orally healthy controls, respectively.
- Subjects
SALIVA analysis; ACUTE phase proteins; IMMUNOASSAY; INFLAMMATION; PERIODONTITIS; PSORIASIS; REFERENCE values; RNA; TRANSFERRIN; GUT microbiome; SEQUENCE analysis
- Publication
Oral Diseases, 2020, Vol 26, Issue 3, p677
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.13277