We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Response of Elderly Veterans to Daily Vitamin D3 Supplementation of 2,000 IU: A Pilot Efficacy Study.
- Authors
Cherniack, E. Paul; Florez, Hermes J.; Hollis, Bruce W.; Roos, Bernard A.; Troen, Bruce R.; Levis, Silvina
- Abstract
To determine the prevalence of hypovitaminosis D (serum 25-hydroxyvitamin D<32 ng/mL; HVD) in a population of elderly veterans and conduct a preliminary assessment of the efficacy of supplementation with cholecalciferol in correcting HVD. Randomized, double-blind, placebo-controlled clinical trial. Geriatric clinic at the Bruce W. Carter Veterans Affairs Medical Center, Miami, Florida. Veterans aged 70 and older. Oral cholecalciferol 2,000 IU daily or placebo for 6 months. Serum calcium, 25-hydroxyvitamin D, parathyroid hormone, and 24-hour urinary calcium. Of the 34 participants who completed the study, 62% had HVD at baseline. In the treatment group, mean serum 25-hydroxyvitamin D level rose from 28.4±7.9 ng/mL at baseline to 42.7±10.5 ng/mL at the end of the trial, but levels remained less than 32 ng/mL in three of 17 (18%) of the participants. In the placebo group, the baseline level of 27.7±8.3 ng/mL remained unchanged (28.8±8.7 ng/mL). Supplementation did not alter serum or urinary calcium levels and did not result in any adverse events. These initial observations suggest that, in older veterans, cholecalciferol 2,000 IU daily for 6 months is generally safe and corrects HVD in most but not all individuals.
- Subjects
OLDER veterans; OLDER people; CHOLECALCIFEROL; PILOT projects; VITAMIN deficiency
- Publication
Journal of the American Geriatrics Society, 2011, Vol 59, Issue 2, p286
- ISSN
0002-8614
- Publication type
Article
- DOI
10.1111/j.1532-5415.2010.03242.x