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- Title
In Vivo Delayed-Type Hypersensitivity Skin Test Anergy in Human Immunodeficiency Virus Type 1 Infection Is Associated with T Cell Nonresponsiveness In Vitro.
- Authors
Maas, J. J.; Roos, M. T. L.; Keet, I. P. M.; Mensen, E. A. M.; Krol, A.; Veenstra, J.; Schellekens, P. T. A.; Jurriaans, S.; Coutinho, R. A.; Miedema, F.
- Abstract
In a cross-sectional study, the prevalence of delayed-type hypersensitivity skin test anergy (DTHA) was examined in 136 asymptomatic human immunodeficiency virus—infected participants in relation to immunologic and virologic parameters. DTHA was assessed with a multitest cell-mediated immunity skin test. Of the 136 participants, with a mean CD4 T cell count of 335 × 106/L, 25 were anergic (18.4%). In the stepwise forward multivariate logistic regression models, after adjustment for CD4 T cell counts, depending on whether it was analyzed continuously or after dichotomization (20th percentile), both T cell reactivity to CD2 plus CD28 antibodies or to CD3 antibodies were the most predictive markers of DTHA (odds ratio, 0.80; 95% confidence interval, 0.67–0.94; and odds ratio, 2.97; 95% confidence interval, 1.1–8.3, respectively). This study shows a strong correlation between the decreased T cell responses in vitro and DTHA. Therefore, next to DTHA testing, T cell function assays may be useful to test immune reconstitution observed during antiretroviral treatment.
- Publication
Journal of Infectious Diseases, 1998, Vol 178, Issue 4, p1024
- ISSN
0022-1899
- Publication type
Article