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- Title
Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with neonatal herpes.
- Authors
Sullender, Wayne M.; Yasukawa, Linda L.; Schwartz, Michelle; Pereira, Lenore; Hensleigh, Paul A.; Prober, Charles G.; Arvin, Ann M.; Sullender, W M; Yasukawa, L L; Schwartz, M; Pereira, L; Hensleigh, P A; Prober, C G; Arvin, A M
- Abstract
We used a murine monoclonal antibody to herpes simplex virus (HSV) type 2 (HSV-2) glycoprotein G (gG) to develop an enzyme immunoassay that detected HSV-2 type-specific antibodies in human sera. Antibodies to HSV-2 gG were detected in 98 (96%) of 102 sera from pregnant women with culture-proved HSV-2 infection. Sixty-five percent of the women had serological evidence of past HSV-2 infection by the Rawls index, based on titers of neutralizing antibody to HSV type 1 and HSV-2. Thirty (88%) of 34 infants exposed to maternal HSV infection at delivery had antibodies to HSV-2 gG and remained well. One infant exposed to primary maternal HSV-2 infection lacked antibodies to HSV-2 gG and developed neonatal HSV-2 infection. The mean ± SD optical density by HSV-2 gG enzyme-linked immunosorbent assay for sera obtained from 17 infants within one week after onset of neonatal HSV-2 infection was 0.25 ± 0.12, compared with 1.15 ± 0.34 in cord blood sera from exposed infants who did not develop symptoms (P < .0001 by t test).
- Publication
Journal of Infectious Diseases, 1988, Vol 157, Issue 1, p164
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/157.1.164