We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study.
- Authors
Krasnoff, Joanne B; Basaria, Shehzad; Pencina, Michael J; Jasuja, Guneet K; Vasan, Ramachandran S; Ulloor, Jagadish; Zhang, Anqi; Coviello, Andrea; Kelly-Hayes, Margaret; D'Agostino, Ralph B; Wolf, Philip A; Bhasin, Shalender; Murabito, Joanne M
- Abstract
<bold>Context: </bold>Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood.<bold>Objective: </bold>Our objective was to examine cross-sectional and prospective relations between baseline sex hormones and mobility limitations and physical performance in community-dwelling older men.<bold>Design, Setting, and Participants: </bold>We conducted cross-sectional and longitudinal analyses of 1445 men (mean age 61.0 +/- 9.5 yr) who attended Framingham Offspring Study examinations 7 and 8 (mean 6.6 yr apart). Total testosterone (TT) was measured by liquid chromatography tandem mass spectrometry at examination 7. Cross-sectional and longitudinal analyses of mobility limitation and physical performance were performed with continuous (per SD) and dichotomized [low TT and free testosterone (FT) and high SHBG vs. normal] hormone levels.<bold>Main Outcome Measures: </bold>Self-reported mobility limitation, subjective health, usual walking speed, and grip strength were assessed at examinations 7 and 8. Short physical performance battery was performed at examination 7.<bold>Results: </bold>Higher continuous FT was positively associated with short physical performance battery score (beta = 0.13; P = 0.008), usual walking speed (beta = 0.02; P = 0.048), and lower risk of poor subjective health [odds ratio (OR) = 0.72; P = 0.01]. In prospective analysis, 1 SD increase in baseline FT was associated with lower risk of developing mobility limitation (OR = 0.78; 95% confidence interval = 0.62-0.97) and progression of mobility limitation (OR = 0.75; 95% confidence interval = 0.60-0.93). Men with low baseline FT had 57% higher odds of reporting incident mobility limitation (P = 0.03) and 68% higher odds of worsening of mobility limitation (P = 0.007).<bold>Conclusions: </bold>Lower levels of baseline FT are associated with a greater risk of incident or worsening mobility limitation in community-dwelling older men. Whether this risk can be reduced with testosterone therapy needs to be determined by randomized trials.
- Subjects
POSTURAL balance; GLYCOPROTEINS; GRIP strength; HEALTH; HIGH performance liquid chromatography; LONGITUDINAL method; MASS spectrometry; MUSCLE strength; RESEARCH funding; TESTOSTERONE; WALKING; SYMPTOMS; CROSS-sectional method; ODDS ratio
- Publication
Journal of Clinical Endocrinology & Metabolism, 2010, Vol 95, Issue 6, p2790
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2009-2680