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- Title
Lactate and Glycerol Release from Subcutaneous Adipose Tissue in Black and White Lean Men.
- Authors
VAN DER MERWE, MARIA-TERÉ SA; JANSSON, PER-ANDERS; CROWTHER, NIGEL J.; BOYD, IVAN H.; GRAY, I. PETER; JOFFE, BARRY I.; LÖNNROTH, PETER N.
- Abstract
To measure interstitial glycerol and lactate production from the sc adipose tissue of two regions in nine black and nine white lean men, sc microdialysis was performed in combination with adipose tissue blood flow rates measured with 133Xe clearance. In the postabsorptive state, the plasma glucose and insulin levels of the black men and white men were similar. The black men had higher plasma free fatty acids (825 6 97 vs. 439 6 58 mmol/L; P , 0.005), glycerol (99.5 6 5.1 vs. 54.1 6 3.3 mmol/L; P , 0.0001), and lactate (1056 6 95 vs. 729 6 45 mmol/L; P , 0.01). Interstitial glycerol concentrations in the black and white men were 227 vs. 163 mmol/L (P , 0.01) and 230 vs. 162 mmol/L (P , 0.05) in the abdominal and femoral regions. The adipose tissue blood flow rate was higher in the black men in the abdominal (7.9 6 0.9 vs. 3.1 6 0.5 mL/100 gzmin; P , 0.01) and femoral area (5.2 6 0.6 vs. 2.8 6 0.3; P , 0.01). Interstitial lactate concentrations in black and white men were 1976 vs. 1364 mmol/L (P , 0.004) and 1953 vs. 1321 mmol/L (P , 0.004) in the abdominal and femoral regions, respectively. Glycerol release was higher in black men vs. white men for abdominal (0.21 6 0.02 vs. 0.14 6 0.02 mmol/100 gzmin; P , 0.02) and femoral (0.22 6 0.02 vs. 0.15 6 0.01; P , 0.05) areas. Postprandially, black men had higher plasma glucose levels [1 h, 9.6 6 0.4 vs. 8.2 6 0.5 mmol/L (P , 0.05); 2 h, 8.9 6 0.4 vs. 7.2 6 0.4 mmol/L (P , 0.01)], but lower plasma insulin levels [1 h, 173 6 13 vs. 264 6 48 pmol/L (P , 0.05); 2 h, 136 6 20 vs. 209 6 34 pmol/L (P , 0.05)]. Plasma free fatty acid, lactate, and glycerol levels remained higher in the black men. After 1 h, lactate release was higher in the black men vs. that in the white men for abdominal (20.5 6 1.6 vs. 14.7 6 2.5 mmol/100 gzmin; P , 0.05) and femoral (15.6 6 1.1 vs. 12.1 6 1.8; P , 0.03) areas. We conclude that the black men, who are relatively insulinopenic postprandially, have a brisker lipolysis and also release more lactate from sc fat tissue than white men. These differences in adipose tissue metabolism may be related to differences in the lipid profiles and glucose metabolism previously documented in these ethnic groups.
- Publication
Journal of Clinical Endocrinology & Metabolism, 1999, Vol 84, Issue 8, p2888
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jcem.84.8.5927