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- Title
Insulin Sensitivity and β-Cell Function in Women With Polycystic Ovary Syndrome.
- Authors
VrbíKová, Jana; Bendlová, Bela; Hill, Martin; Vanková, Markéta; Vondra, Karel; Stárka, Luboslav
- Abstract
OBJECTIVE -- To evaluate insulin sensitivity (IS) and β-cell function (βF) in lean and obese women with polycystic ovary syndrome (PCOS), either separately or by using a disposition index (DI). RESEARCH DESIGN AND METHODS-- A total of 64 women with PCOS and 20 healthy women were examined by anthropometry, oral glucose tolerance tests (OGTTs), and insulin tolerance tests. Statistical analysis used one-way ANOVA, Kruskal-Wallis, and Mann-Whitney U tests, as appropriate. RESULTS -- A significantly higher waist-to-hip ratio (P < 0.0001) was found in both lean and obese women with PCOS. Higher basal blood glucose (P < 0.004) and blood glucose values at 3 h of OGTT (P < 0.008) were found in lean and obese PCOS subjects in comparison with control subjects. Insulin resistance by homeostasis model assessment (P < 0.007) was significantly higher in obese PCOS than in control or lean PCOS subjects. Early-phase insulin secretion (insulinogenic index [ΔI/ΔG30-0, where I is insulin and G is glucose]; P < 0.0007) was significantly higher in both lean and obese PCOS subjects than in healthy women. All tested combinations of parameters of IS and βF (DIs) followed a physiological hyperbolic relationship. Significantly lower values of the fasting state-derived DIs were found (all P < 0.05) in obese PCOS subjects. Significantly higher values of all of these indexes derived from nonfasting values were found in lean PCOS as compared with control and obese PCOS subjects (all P < 10-3). CONCLUSIONS--Increased βF was found even in lean individuals with PCOS. Insulin hypersecretion is thus probably connected to the pathogenesis of PCOS.
- Subjects
INSULIN resistance; PANCREATIC beta cells; OVERWEIGHT women; POLYCYSTIC ovary syndrome; DISEASES
- Publication
Diabetes Care, 2002, Vol 25, Issue 7, p1217
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/diacare.25.7.1217