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- Title
Promotion and acceleration of diabetic ulcer healing by arginine-glycine-aspartic acid (RGD) peptide matrix. RGD Study Group.
- Authors
Steed, David L.; Ricotta, John J.; Prendergast, J. Joseph; Kaplan, Robert J.; Webster, Marshall W.; McGill, Janet B.; Schwartz, Sherwyn L.; Steed, D L; Ricotta, J J; Prendergast, J J; Kaplan, R J; Webster, M W; McGill, J B; Schwartz, S L
- Abstract
<bold>Objective: </bold>To determine the effectiveness and safety of arginine-glycine-aspartic acid (RGD) peptide matrix in the treatment of diabetic foot ulcers.<bold>Research Design and Methods: </bold>This randomized placebo-controlled investigator- and patient-blinded prospective multicenter investigation was conducted at three institutional and three private U.S. clinics providing ambulatory care. Sixty-five diabetic patients with chronic full-thickness neurotrophic foot ulcers were enrolled. Six discontinued the study because of adverse events. RGD peptide matrix (Argidene Gel; formerly Telio-Derm Gel) was applied topically twice weekly for up to 10 weeks in patients who otherwise received standard care. Control group patients received topical saline as a placebo plus standard care. The primary method of assessment was the incidence and rate of ulcer closure. All patients enrolled were included in the data analysis.<bold>Results: </bold>The percentage of patients whose ulcers healed completely in the RGD peptide matrix group (35%; 14 of 40 patients) was over fourfold greater (P = 0.02) than that in the placebo group (8%; 2 of 25 patients). By the study end point (either day of healing or week 10), 30 of 40 (75%) RGD peptide matrix patients had achieved > 50% ulcer closure compared with 12 of 25 (48%) placebo patients (P = 0.03). RGD peptide matrix also significantly (P = 0.03) increased the rate of ulcer closure over the 10 weeks of the study.<bold>Conclusions: </bold>RGD peptide matrix treatment promoted and accelerated the healing of chronic diabetic foot ulcers to a significant degree.
- Publication
Diabetes Care, 1995, Vol 18, Issue 1, p39
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.18.1.39