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- Title
Lack of effects of hypoglycemia on glucose absorption in healthy men.
- Authors
Møller, Jens; Laker, Michael F.; Gillespie, Susan M.; Ovesen, Per G.; Abildgaard, Niels; Tian, Rong; Jørgensen, Jens O. L.; Møller, Niels; Møller, J; Laker, M F; Gillespie, S M; Ovesen, P G; Abildgaard, N; Tian, R; Jørgensen, J O; Møller, N
- Abstract
<bold>Objective: </bold>To assess the effects of hypoglycemia on glucose absorption by examining the systemic appearance of 3-OMG (a glucose analogue that is transported by the same mechanism as glucose) after oral administration.<bold>Research Design and Methods: </bold>Six healthy males 22-31 yr of age were studied during a hypoglycemic (50 mg [2.7 mM]/100 ml) and a euglycemic (90 mg [5.0 mM]/100 ml) glucose clamp. At 50 min after exposure to insulin, an oral glucose load containing 20 g of glucose and 4.5 g of 3-OMG dissolved in 300 ml of tap water was administered. Insulin administration was interrupted 30 min after oral glucose administration.<bold>Results: </bold>Plasma glucose was clamped at 88 +/- 1.3 mg (4.9 +/- 0.1 mM)/100 ml during euglycemia and at 50 +/- 1.9 mg (2.7 +/- 0.1 mM)/100 ml during hypoglycemia. Concentrations of glucagon, growth hormone, cortisol, and epinephrine were significantly elevated during hypoglycemia. After 60 min, circulating 3-OMG concentrations increased to zeniths of 11.4 +/- 0.2 mg (585 +/- 10.0 mM)/100 ml (hypoglycemia) and 11.6 +/- 1.1 mg (585 +/- 56.0 microM)/100 ml (euglycemia; P = 0.95). Absorption of 3-OMG was evident between 15 and 20 min after administrations in both situations. Serum insulin was significantly lower during hypoglycemia compared with the control situation (345 +/- 50 microM [hypoglycemia], 445 +/- 50 microM [euglycemia], P = 0.03).<bold>Conclusions: </bold>We conclude that hypoglycemia does not seem to affect intestinal absorption of glucose as judged by systemic appearance of 3-OMG.
- Publication
Diabetes Care, 1992, Vol 15, Issue 10, p1264
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.15.10.1264