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- Title
High Frequency of MYD88 L265P Mutation in Primary Ocular Adnexal Marginal Zone Lymphoma and Its Clinicopathologic Correlation: A Study From a Single Institution.
- Authors
Amir Behdad; Xiao Yi Zhou; Juehua Gao; Raparia, Kirtee; Dittman, David; Green, Stefan J.; Chao Qi; Betz, Bryan; Bryar, Paul; Qing Chen; Yi-Hua Chen
- Abstract
Context.--The pathogenesis of primary ocular adnexal marginal zone lymphoma (POAMZL) remains unclear. The reported associations with Chlamydia psittaci infection and MYD88 mutations are highly variable. Objective.--To examine MYD88 L265P mutation in ocular marginal zone lymphomas and correlate with clinicopathologic features and Chlamydia infection. Design.--Presence of MYD88 L265P mutation and Chlamydia infection in lymphoma was analyzed by using sensitive polymerase chain reaction (PCR) methods. Results.--The MYD88 L265P mutation was identified in 8 of 22 POAMZLs (36%), including 2 of 3 cases in which PCR failed to detect clonal IGH gene rearrangement; none of the 4 secondary marginal zone lymphomas were positive. Test results for Chlamydia were negative in all cases. Patients with and without the MYD88 mutation had similar clinicopathologic features. Conclusions.--The MYD88 mutational analysis provides important information in diagnostic workup of POAMZL. The frequent MYD88 mutation suggests a critical role of this aberration in the pathogenesis of POAMZL and may serve as a therapeutic target for patients with progressive disease.
- Subjects
CHLAMYDIA infection diagnosis; OCULAR tumors; GENETIC mutation; LYMPHOMAS; POLYMERASE chain reaction; DISEASE progression; GENETICS
- Publication
Archives of Pathology & Laboratory Medicine, 2019, Vol 143, Issue 4, p483
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/arpa.2018-0092-oa