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- Title
RELATED FACTORS FOR COLONIZATION BY Candida SPECIES IN THE ORAL CAVITY OF HIV-INFECTED INDIVIDUALS.
- Authors
de Paula MENEZES, Ralciane; BORGES, Aércio Sebastião; de ARAUJO, Lúcio Borges; dos Santos PEDROSO, Reginaldo; Von Dolinger de Brito RÖDER, Denise
- Abstract
The colonization of the oral cavity is a prerequisite to the development of oropharyngeal candidiasis. Aims: The aims of this study were: to evaluate colonization and quantify Candida spp. in the oral cavity; to determine the predisposing factors for colonization; and to correlate the levels of CD4+ cells and viral load with the yeast count of colony forming units per milliliter (CFU/mL) in HIV-positive individuals treated at a University Hospital. Saliva samples were collected from 147 HIV patients and were plated on Sabouraud Dextrose Agar (SDA) and chromogenic agar, and incubated at 30 °C for 72 h. Colonies with similar morphology in both media were counted and the result expressed in CFU/mL. Results: Of the 147 HIV patients, 89 had positive cultures for Candida spp., with a total of 111 isolates, of which C. albicans was the most frequent species (67.6%), and the mean of colonies counted was 8.8 × 10³ CFU/mL. The main predisposing factors for oral colonization by Candida spp. were the use of antibiotics and oral prostheses. The use of reverse transcriptase inhibitors appears to have a greater protective effect for colonization. A low CD4+ T lymphocyte count is associated with a higher density of yeast in the saliva of HIV patients.
- Subjects
HIV infection complications; SALIVA analysis; THRUSH (Mouth disease); VIRAL load; COLONIZATION (Ecology); CD4 antigen
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2015, Vol 57, Issue 5, p413
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S0036-46652015000500008