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- Title
Designer TALEs team up for highly efficient gene induction.
- Authors
Richter, Annekatrin; Boch, Jens
- Abstract
The authors discuss the study that generates a total of 70 designer transcription activator-like effectors (TALEs) induce three human genes. They argue that the researchers achieved induction rates of up to 114-fold over basal transcription. They contend that the researchers successfully designed TALEs that bind either DNA strand up- or downstream of the natural transcription start site. They note that the study transfected combinations of five or six TALEs for each of the three genes studied.
- Subjects
GENETIC research; GENES; GENETIC transcription; HEREDITY; MOLECULAR genetics
- Publication
Nature Methods, 2013, Vol 10, Issue 3, p207
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.2373