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- Title
Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study.
- Authors
Mei-Ling Liu; Xiao-Tong Zhang; Xiang-Yu Du; Zheng Fang; Zhao Liu; Yi Xu; Peng Zheng; Xue-Jiao Xu; Peng-Fei Cheng; Ting Huang; Shun-Jie Bai; Li-Bo Zhao; Zhi-Guo Qi; Wei-Hua Shao; Peng Xie
- Abstract
Background: Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose this disorder. The aim of the present study was to characterize the alternations of glucose metabolites and identify potential diagnostic biomarkers for schizophrenia. Methods: Gas chromatography/mass spectrometry based targeted metabolomic method was used to quantify the levels of 13 glucose metabolites in peripheral blood mononuclear cells (PBMCs) derived from healthy controls, schizophrenia and major depression subjects (n = 55 for each group). Results: The majority (84.6%) of glucose metabolites were significantly disturbed in schizophrenia subjects, while only two (15.4%) glucose metabolites were differently expressed in depression subjects relative to healthy controls in both training set (n = 35/group) and test set (n = 20/group). Antipsychotics had only a subtle effect on glucose metabolism pathway. Moreover, ribose 5-phosphate in PBMCs showed a high diagnostic performance for first-episode drug-naïve schizophrenia subjects. Conclusion: These findings suggested disturbance of glucose metabolism may be implicated in onset of schizophrenia and could aid in development of diagnostic tool for this disorder.
- Subjects
SCHIZOPHRENIA; MENTAL illness; GLUCOSE metabolism; MENTAL depression; ANTIPSYCHOTIC agents
- Publication
Journal of Translational Medicine, 2015, Vol 13, Issue 1, p1
- ISSN
1479-5876
- Publication type
Article
- DOI
10.1186/s12967-015-0540-y