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- Title
Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients.
- Authors
Kilvaer, Thomas K.; Valkov, Andrej; Sorbye, Sveinung W.; Smeland, Eivind; Bremnes, Roy M.; Busund, Lill-Tove; Donnem, Tom
- Abstract
<bold>Background: </bold>Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor receptor-3 (VEGFR-3), are strongly involved in angiogenesis. This study investigates the prognostic impact of FGF2 and FGFR-1 and explores the impact of their co-expression with PDGF-B and VEGFR-3 in widely resected tumors from non-GIST STS patients.<bold>Methods: </bold>Tumor samples from 108 non-GIST STS patients were obtained and tissue microarrays were constructed for each specimen. Immunohistochemistry was used to evaluate the expressions of FGF-2, FGFR-1, PDGF-B and VEGFR-3.<bold>Results: </bold>In the multivariate analysis, high expression of FGF2 (P = 0.024, HR = 2.2, 95% CI 1.1-4.4) and the co-expressions of FGF2 & PDGF-B (overall; P = 0.007, intermediate; P = 0.013, HR = 3.6, 95% CI = 1.3-9.7, high; P = 0.002, HR = 6.0, 95% CI = 2.0-18.1) and FGF2 & VEGFR-3 (overall; P = 0.050, intermediate; P = 0.058, HR = 2.0, 95% CI = 0.98-4.1, high; P = 0.028, HR = 2.6, 95% CI = 1.1-6.0) were significant independent prognostic indicators of poor disease-specific survival.<bold>Conclusion: </bold>FGF2, alone or in co-expression with PDGF-B and VEGFR-3, is a significant independent negative prognosticator in widely resected non-GIST STS patients.
- Subjects
FIBROBLAST growth factors; PEPTIDES; PLATELET-derived growth factor; NEOVASCULARIZATION; BLOOD proteins
- Publication
Journal of Translational Medicine, 2011, Vol 9, Issue 1, p104
- ISSN
1479-5876
- Publication type
journal article
- DOI
10.1186/1479-5876-9-104