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- Title
Investigation of radiomics models for predicting biochemical recurrence of advanced prostate cancer on pretreatment MR ADC maps based on automatic image segmentation.
- Authors
Wang, Huihui; Wang, Kexin; Ma, Shuai; Gao, Ge; Wang, Xiaoying
- Abstract
Objectives: To develop radiomics models based on automatic segmentation of the pretreatment apparent diffusion coefficient (ADC) maps for predicting the biochemical recurrence (BCR) of advanced prostate cancer (PCa). Methods: A total of 100 cases with pathologically confirmed PCa were retrospectively included in this study. These cases were randomly divided into training (n = 70) and test (n = 30) datasets. Two predictive models were constructed based on the combination of age, prostate specific antigen (PSA) level, Gleason score, and clinical staging before therapy and the prostate area (Model_1) or PCa area (Model_2). Another two predictive models were constructed based on only prostate area (Model_3) or PCa area (Model_4). The area under the receiver operating characteristic curve (ROC AUC) and precision‐recall (PR) curve analysis were used to analyze the models' performance. Results: Sixty‐five patients without BCR (BCR−) and 35 patients with BCR (BCR+) were confirmed. The age, PSA, volume, diameter and ADC value of the prostate and PCa were not significantly different between the BCR− and BCR+ groups or between the training and test datasets (all p > 0.05). The AUCs were 0.637 (95% CI: 0.434–0.838), 0.841 (95% CI: 0.695–0.940), 0.840 (95% CI: 0.698–0.983), and 0.808 (95% CI: 0.627–0.988) for Model_1 to Model_4 in the test dataset without significant difference. The 95% bootstrap confidence intervals for the areas under the PR curve of the four models were not statistically different. Conclusion: The radiomics models based on automatically segmented prostate and PCa areas on the pretreatment ADC maps developed in our study can be promising in predicting BCR of advanced PCa.
- Subjects
RADIOMICS; PROSTATE cancer; IMAGE segmentation; PROSTATE-specific antigen; RECEIVER operating characteristic curves; BIOCHEMICAL models; ENDORECTAL ultrasonography
- Publication
Journal of Applied Clinical Medical Physics, 2024, Vol 25, Issue 4, p1
- ISSN
1526-9914
- Publication type
Article
- DOI
10.1002/acm2.14244