We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto’s thyroiditis.
- Authors
Shoko Nakayama; Taiji Yokote; Kichinosuke Kobayashi; Yuji Hirata; Tetsuya Hiraiwa; Toshikazu Akioka; Takuji Miyoshi; Takayuki Takubo; Motomu Tsuji; Toshiaki Hanafusa
- Abstract
Abstract We describe a case of acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto’s thyroiditis. In Hashimoto’s thyroiditis, the leukocyte function-associated antigen-1 (LFA-1)/intercellular vascular cell adhesion molecule-1 (ICAM-1) and very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) pathways in T lymphocytes and the vascular endothelium both play a role in the initiation and enhancement of lymphocyte recruitment to the thyroid glands during an autoimmune attack. The leukemic blast cells were positive for VLA-4 and negative for LFA-1 by immunohistochemistry. The presence of VLA-4 in blast cells might play a key role in the migration of blast cells to the thyroid glands.
- Subjects
ACUTE myeloid leukemia; THYROID diseases; AUTOIMMUNE thyroiditis; DISEASE complications; CASE studies; LEUCOCYTES; CELL adhesion; IMMUNOHISTOCHEMISTRY
- Publication
Endocrine (1355008X), 2009, Vol 36, Issue 1, p147
- ISSN
1355-008X
- Publication type
Article
- DOI
10.1007/s12020-009-9173-3