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- Title
Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM).
- Authors
Mikołajczyk, Mateusz; Wirstlein, Przemysław; Adamczyk, Magdalena; Skrzypczak, Jana; Wender-Ożegowska, Ewa
- Abstract
Background: Preterm premature rupture of membranes (pPROM) is associated with a high risk of prematurity and complications of fetal inflammatory response syndrome (FIRS). The aim of the study is to determine any correlations between the concentration of selected cytokines contained in the cervicovaginal secretion eluates and in the umbilical cord plasma in patients with pPROM and to find the noninvasive markers of FIRS in order to pinpoint the optimal time of the delivery. Methods: The study included 80 patients with pPROM between the 24th and 34th week of gestation. The cervicovaginal fluid and umbilical cord blood were collected. Interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 19 (IL-19) and tumor necrosis factor-α (TNF-α) concentrations were measured in both materials. For the statistical analysis, SigmaStat3.5 software was used. Results: There was no direct association in levels of IL-6, TNF-α, IL-10 and IL-19 between the cord blood and cervicovaginal secretions within the studied group. The cut-off point of IL-6 of 26.8 pg/mL in the vaginal fluid had high sensitivity and specificity in order to discriminate between newborns with and without FIRS (81.08%; 76.74%). Conclusion: Further studies are needed on a larger group of participants to demonstrate that an elevated concentration of IL-6 above 26.8 pg/mL in the cervicovaginal secretion eluate is an indirect noninvasive marker of FIRS.
- Subjects
CYTOKINES; DELIVERY (Obstetrics); CORD blood; FETAL diseases; FLUIDS; GESTATIONAL age; PREMATURE infants; INTERLEUKINS; PREGNANCY complications; TUMOR necrosis factors; VAGINA; DATA analysis software; SYSTEMIC inflammatory response syndrome
- Publication
Journal of Perinatal Medicine, 2020, Vol 48, Issue 3, p249
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2019-0280