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- Title
Reference range of fetal myocardial area by three-dimensional ultrasonography and its applicability in fetuses of pre-gestational diabetic women.
- Authors
Melo Júnior, José Francisco; Bravo-valenzuela, Nathalie Jeanne; Machado Nardozza, Luciano Marcondes; Borges Peixoto, Alberto; Mattar, Rosiane; Martins, Wellington P.; Tonni Júnior, Gabriele; Araujo, Edward
- Abstract
Objective: To determine the reference range for the myocardial area in healthy fetuses using three-dimensional (3D) ultrasonography and validate these results in fetuses of pregnant women with pre-gestational diabetes mellitus (DM). Methods: This cross-sectional retrospective study included 168 healthy pregnant women between gestational weeks 20 and 33 + 6 days. The myocardial area was measured using spatio-temporal image correlation (STIC) in the four-chamber view. Polynomial regression models were used, and the goodness of fit of the models were evaluated by the coefficient of determination (R²). Intra- and inter-observer reproducibility was determined using the concordance correlation coefficient (CCC). Validation was performed in 30 pregnant women with pre-gestational DM. Results: There was a strong correlation (R² = 0.71, P < 0.0001) between myocardial area and gestational age. There was good intra- and inter-observer reproducibility, with a CCC of 0.86 and 0.83, respectively. However, there was no significant difference in the mean myocardial area between healthy fetuses and fetuses of women with pre-gestational DM (0.11 cm², P = 0.55). Conclusion: The reference range was determined for the myocardial area in fetuses, and there was no significant difference in this variable between healthy fetuses and the fetuses of women with pre-gestational DM.
- Subjects
FETAL echocardiography; STATISTICAL correlation; DIABETES; FETAL heart; FETAL ultrasonic imaging; GESTATIONAL age; GOODNESS-of-fit tests; MYOCARDIUM; PREGNANT women; REFERENCE values; REGRESSION analysis; RESEARCH evaluation; THREE-dimensional imaging; INTER-observer reliability; CROSS-sectional method; RETROSPECTIVE studies; FETUS
- Publication
Journal of Perinatal Medicine, 2019, Vol 47, Issue 4, p422
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2018-0342