We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bacterial gene amplification: implications for the evolution of antibiotic resistance.
- Authors
Sandegren, Linus; Andersson, Dan I.
- Abstract
Recent data suggest that, in response to the presence of antibiotics, gene duplication and amplification (GDA) constitutes an important adaptive mechanism in bacteria. For example, resistance to sulphonamide, trimethoprim and β-lactams can be conferred by increased gene dosage through GDA of antibiotic hydrolytic enzymes, target enzymes or efflux pumps. Furthermore, most types of antibiotic resistance mechanism are deleterious in the absence of antibiotics, and these fitness costs can be ameliorated by increased gene dosage of limiting functions. In this Review, we highlight the dynamic properties of gene amplifications and describe how they can facilitate adaptive evolution in response to toxic drugs.
- Subjects
GENE amplification; BACTERIAL genetics; DRUG resistance in microorganisms; BETA lactamases; ANTIBIOTICS; MICROBIOLOGY
- Publication
Nature Reviews Microbiology, 2009, Vol 7, Issue 8, p578
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2174