The article cites a study that uses a global transcriptome approach in studying the comparability of the pathogenic strategies of viruses in different cell types. Pseudorabies virus (PRV) and herpes simplex virus type 1 (HSV-1) are alpha-herpesviruses that have conserved genome organization, virion structure and replication cycles. It is observed that there are changes in oxidative-stress gene transcription late in both PRV and HSV-1 infection.