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- Title
Clinical effects of multi-oil versus pure soybean oil-based lipid emulsions for preterm infants: An observational study.
- Authors
Xing Li; Rui Zhao; Hai-Feng Lv; Miao-Fa Ying; Zhou Jiang
- Abstract
Background and Objectives: Conventional soybean oil-based intravenous lipid emulsions (SO-ILEs) have high polyunsaturated fatty acid (PUFA) contents and phytosterols that may have adverse effects in preterm infants. Recently, the multi-oil-based intravenous lipid emulsion (MO-ILE), SMOFlipid, has been widely utilized in the neonatal intensive care unit (NICU), but significant benefits over SO-ILEs in low gestational age neonates have yet to be demonstrated. This study was performed to compare the effects of the SO-ILE, Intralipid, and the MOILE, SMOFlipid, on neonatal health outcomes in preterm infants. Methods and Study Design: We performed a retrospective review of preterm infants born at gestational week (GW) <32 receiving parenteral nutrition for longer durations (≥14 d) in the NICU between 2016 and 2021. The primary aim of this study was to investigate differences in morbidity between preterm infants receiving SMOFlipid and Intralipid. Results: A total of 262 preterm infants were included in the analysis, with 126 receiving SMOFlipid and 136 receiving Intralipid. The SMOFlipid group had lower rates of ROP (23.8% vs 37.5%, respectively; p=0.017), although the rate of ROP was not different in multivariate regression analysis. The length of hospital stay was significantly shorter in the SMOFlipid than SO-ILE group (median [IQR]=64.8 [37] vs 72.5 [49] days; p<0.001). Conclusions: The use of SMOFlipid as the lipid emulsion was associated with higher clinical efficacy than SO-ILE in preterm infants.
- Subjects
PREMATURE infants; PHYTOSTEROLS; INTRAVENOUS fat emulsions; NEONATAL intensive care units; UNSATURATED fatty acids; SOYBEAN
- Publication
Asia Pacific Journal of Clinical Nutrition, 2023, Vol 32, Issue 1, p77
- ISSN
0964-7058
- Publication type
Article
- DOI
10.6133/apjcn.202303_32(1).0012