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- Title
Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer.
- Authors
Pei-Hung Chang; Jason Chia-Hsun Hsieh; Kun-Yun Yeh; Eric Yen-Chao Chen; Shih-Wei Yang; Jen-Seng Huang; Chien-Hong Lai; Tsung-Han Wu; Yen-Min Huang; Yueh-Shih Chang; Wen-Chi Chou; Cheng-Hsu Wang; Chang, Pei-Hung; Hsieh, Jason Chia-Hsun; Yeh, Kun-Yun; Chen, Eric Yen-Chao; Yang, Shih-Wei; Huang, Jen-Seng; Lai, Chien-Hong; Wu, Tsung-Han
- Abstract
<bold>Background and Objectives: </bold>This study was designed to evaluate the impact of the prognostic nutritional index (PNI) on treatment-related toxicities and tolerance in patients with advanced head and neck cancers who were undergoing concurrent chemoradiotherapy (CCRT).<bold>Methods and Study Design: </bold>We retrospectively analyzed and compared the clinical characteristic, toxicities and survival of 143 patients with stage III, IVA, and IVB head and neck cancer who were treated with CCRT according to their PNI between 2007 and 2010.<bold>Results: </bold>Low PNI was correlated with T classification and advanced tumor stage. Patients with low PNI were less likely to tolerate CCRT, required tube feeding support more frequently and had higher percentages of grade 3/4 hematological toxicities, sepsis and toxic death.<bold>Conclusions: </bold>Pretreatment PNI predicts treatment-tolerance and toxicity in patients with advanced head and neck cancer undergoing CCRT.
- Subjects
CHEMORADIOTHERAPY; HYPOPHARYNGEAL cancer; TUMOR growth; HEMATOLOGY; HEAD &; neck cancer
- Publication
Asia Pacific Journal of Clinical Nutrition, 2018, Vol 27, Issue 5, p996
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.032018.04