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- Title
Contribution of hypoalbuminemia and decreased renal function to the increased mortality after newly diagnosed vertebral fracture in Japanese subjects.
- Authors
Tetsuo Nakano; Akiko Kuwabara; Hiroshi Mizuta; Kiyoshi Tanaka; Nakano, Tetsuo; Kuwabara, Akiko; Mizuta, Hiroshi; Tanaka, Kiyoshi
- Abstract
<bold>Background and Objectives: </bold>Reports on the mortality and its contributing factors after vertebral fracture (VFx) has been scarce, and limited to prevalent VFx. In this paper, we have studied the factors influencing mortality after freshly diagnosed VFx.<bold>Methods and Study Design: </bold>759 subjects aged 78.8±8.5 years old with back or lumbar pain, and diagnosed as fresh VFx by MRI were studied for their age, gender, number of prevalent fracture (s), survival or the date of death, circulating concentrations of Hb, albumin, C reactive protein, and estimated glomerular filtration rate (eGFR). Cox's proportional hazard analysis was performed to assess the significant predictors for mortality. The cut-off concentrations of the variables for mortality were analyzed using the receiver operator characteristic (ROC) curve.<bold>Results: </bold>The median observation duration was 3.8 years, and 3-year survival rate was 78.8%. Cox's proportional hazard analysis has shown that serum albumin concentration (hazard ratio (HR) =0.355) and eGFR (HR=0.993) were significant predictors for mortality. The cut-off concentrations were 3.6 g/dL and 60 mL/min/1.73m2, respectively. Kaplan-Meier curves revealed that survival rates were significantly decreased in patients with both serum albumin concentration and eGFR below these cut-off concentrations.<bold>Conclusions: </bold>The present study has revealed that malnutrition and impaired renal function were significant predictors for mortality after VFx.
- Subjects
JAPAN; BONE fractures; DIAGNOSIS of bone fractures; DISEASE prevalence; LUMBAR pain; GLOMERULAR filtration rate; PATIENTS; MALNUTRITION; BLOOD protein disorders; C-reactive protein; HEMOGLOBINS; KIDNEYS; MAGNETIC resonance imaging; SERUM albumin; SPINAL injuries; PROPORTIONAL hazards models; DISEASE complications
- Publication
Asia Pacific Journal of Clinical Nutrition, 2016, Vol 25, Issue 3, p472
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.092015.17