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- Title
Hepatoprotector Effect of Moringa Seed Extract Through Decreasing Interleukin-1b and Tumor Necrosis Factor-α Expression and Cholesterol Total Level in Hepatic Metabolic Syndrome Rats.
- Authors
Rezkita, Bastomy Eka; Dhelima, Ismi Cahya
- Abstract
Background/Aims Metabolic syndrome related with high of cholesterol total level and tumor necrosis factor (TNF)-α, and interleukin (IL)-1β. They are some high risk factor of nonalcoholic fatty liver disease. Moringa oleifera have secondary metabolite that potentially can reduce cholesterol and inflammation process. This research intend to determine the effect of Moringa seed extract as hepatoprotector through decreasing TNF-α and IL-1 β expression and cholesterol total level in hepatic metabolic syndrome rats. Methods This posttest only group design. Rats were divided into four groups: K1 were control group, K2 were metabolic syndrome rats, K3 and K4 were metabolic syndrome rats model and given Moringa seeds extract dose 150 mg/KgBW and 200 mg/KgBW. Effect of high fat fructose diet and Moringa seeds extract to the expression of TNF-α and IL-1β in hepatic tissue were analyzed with analysis of variance (ANOVA) continued with Tukey whereas effect to cholesterol total of rats were analyzed with Friedman test, Wilcoxon test, ANOVA test, and Tukey HSD. Results One-way ANOVA test showed a significant difference of IL-1β and TNF-α expression between four group (p<0.05). Tukey HSD post hoc test showed a significant difference (p<0.05). But there were not significant difference in K1 and K4 (p>0.05). Cholesterol test with Friedman test continued with Wilcoxon test showed that there were significant (p<0.05) on day 0, day 54, and day 82 (p<0.05). One-way ANOVA test and pH Tukey HSD showed that there were significant (p<0.05). Conclusions Moringa seeds extract can potentially reduce cholesterol level total and expression of IL-1β and TNF-α.
- Subjects
CHOLESTEROL content of food; METABOLIC syndrome; MORINGA; CHOLESTEROL; TUMOR necrosis factors; FATTY liver; HIGH-fat diet
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p93
- ISSN
1976-2283
- Publication type
Article