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- Title
Raman reporter-coated gold nanorods and their applications in multimodal optical imaging of cancer cells.
- Authors
Li Jiang; Jun Qian; Fuhong Cai; Sailing He
- Abstract
We report the preparation of a kind of surface-enhanced Raman scattering (SERS) tags and explore their applications in multifunctional optical imaging of cancer cells. The proposed nanoparticles (SERS tags) are prepared by connecting dye molecules directly onto the surfaces of gold nanorods through Au-S or Au-N interactions. The dye molecules are used as Raman reporters, while gold nanorods are used as enhanced materials due to their localized surface plasmon resonance effect. Multilayered polymers are further coated onto the surfaces of the nanoparticles to reach better stability and biocompatibility. Gold nanorods with different aspect ratios and different dye molecules conjugated are compared in order to achieve the diversity of SERS tags and find out the optimized condition of SERS tags with the highest signal intensity. Our experiments show that the resulting nanoparticles, which are uptaken by cancer cells, can provide not only dark field cells images but also multiplexing SERS images. [Figure not available: see fulltext.]
- Subjects
CANCER cells; GOLD; SURFACE enhanced Raman effect; NANOPARTICLES; SURFACE plasmon resonance
- Publication
Analytical & Bioanalytical Chemistry, 2011, Vol 400, Issue 9, p2793
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-011-4894-6