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- Title
Mina53 regulates the differentiation and proliferation of leukemia cells.
- Authors
Zhou, Lixiao; Zhang, Ting; Zhu, Qiang; Zhang, Pengcheng; Yu, Liyang; Shen, Binghui; Yi, Wen; Qiu, Mengsheng; Zhu, Chenggang
- Abstract
The mRNA levels of p21, which regulates the cell cycle progression and cell proliferation, were upregulated by almost twofold in both HL-60 cells and K562 cells. ATRA is known to induce cell differentiation and inhibit cell proliferation in leukemia cells.[5] Consistently, we observed an obvious cell differentiation and a significant reduction in cell proliferation when treating HL-60 cells with ATRA (Figure A,B).
- Subjects
CELL proliferation
- Publication
Hematological Oncology, 2019, Vol 37, Issue 4, p513
- ISSN
0278-0232
- Publication type
letter
- DOI
10.1002/hon.2621