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- Title
Preparation and characterization of poly(ethylene oxide)-loaded hydroxypropyl- β-cyclodextrin nanofibers.
- Authors
Hossain, M. Forhad; Gong, R. Hugh; Rigout, Muriel
- Abstract
Hydroxypropyl- β-cyclodextrin (HP- β-CD) is a modified β-cyclodextrin ( β-CD) derivative, which is toxicologically harmless to mammals and other animals. HP- β-CD is electrospun from an aqueous solution by blending with a non-toxic, biocompatible, synthetic polymer poly(ethylene oxide) (PEO). Aqueous solutions containing different HP- β-CD/PEO blends (50:50-80:20) with variable concentrations (4 wt%-12 wt%) were used. Scanning electron microscope was used to investigate the morphology of the fibers, and Fourier transform infrared spectroscopy analysis confirmed the presence of HP- β-CD in the fiber. Uniform nanofibers with an average diameter of 264, 244, and 236 nm were obtained from 8 wt% solution of 50:50, 60:40, and 70:30 HP- β-CD/PEO, respectively. The average diameter of the fiber was decreased with increasing of HP- β-CD/PEO ratio. However, a higher proportion of HP- β-CD in the spinning solution increased beads in the fibers. The polymer concentration had no significant effect on the fiber diameter. The most uniform fibers with the narrowest diameter distribution were obtained from the 8 wt% of 50:50 solution. Copyright © 2015 John Wiley & Sons, Ltd.
- Subjects
PROPAFENONE; CYCLODEXTRINS synthesis; ETHYLENE oxide; ETHYLENE crystals; EPOXY compounds
- Publication
Polymers for Advanced Technologies, 2015, Vol 26, Issue 9, p1184
- ISSN
1042-7147
- Publication type
Article
- DOI
10.1002/pat.3552