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- Title
Discovery of the New Plant Growth-Regulating Compound LYXLF2 Based on Manipulating the Halogenase in Amycolatopsis orientalis.
- Authors
Xu, Li; Han, Ting; Ge, Mei; Zhu, Li; Qian, XiuPing
- Abstract
Analysis of the Amycolatopsis orientalis HCCB10007 genome revealed new gene clusters involved in natural product biosynthesis that were not associated with the production of known compounds. Halogenases are a type of tailoring enzymes that are usually found within these secondary gene clusters. In this study, we identified an indole-type halometabolite 6-chrolo-1H-indole-3-carboxamide, named LYXLF2, by whole genome mining and metabolic profiling of a flavin-dependent halogenase mutant. LYXLF2 is a new plant growth-regulating compound that promotes root elongation. The results of this study demonstrated that the special gene knock-out/comparative metabolic profiling approach provides a powerful tool for the discovery of novel natural products by genome mining.
- Subjects
PLANTS; MICROBIOLOGY; PLANT regulators; AMYCOLATOPSIS; PLANT growth; BACTERIAL genomes; NATURAL products; HALOGENASES
- Publication
Current Microbiology, 2016, Vol 73, Issue 3, p335
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s00284-016-1052-6