We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathophysiology and clinical relevance of atrial myopathy.
- Authors
Tubeeckx, Michiel R. L.; De Keulenaer, Gilles W.; Heidbuchel, Hein; Segers, Vincent F. M.
- Abstract
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria and is the substrate for development of atrial fibrillation, the most common arrhythmia. Pathophysiologic mechanisms driving atrial myopathy are inflammation, oxidative stress, atrial stretch, and neurohormonal signals, e.g., angiotensin-II and aldosterone. These mechanisms initiate the structural and functional remodeling of the atrial myocardium. Novel therapeutic strategies are being developed that target the pathophysiologic mechanisms of atrial myopathy. In this review, we will discuss the pathophysiology of atrial myopathy, as well as diagnostic and therapeutic strategies.
- Subjects
MUSCLE diseases; PATHOLOGICAL physiology; ATRIAL fibrillation; ATRIUMS (Architecture); OXIDATIVE stress
- Publication
Basic Research in Cardiology, 2024, Vol 119, Issue 2, p215
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s00395-024-01038-0