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- Title
Prognostic Factors and Multidisciplinary Postoperative Chemoradiotherapy for Clinical T4a Tongue Cancer.
- Authors
Yokota, Tomoya; Iida, Yoshiyuki; Ogawa, Hirofumi; Kamijo, Tomoyuki; Onozawa, Yusuke; Todaka, akiko; Hamauchi, Satoshi; Onoe, Tsuyoshi; Nakagawa, Masahiro; Yurikusa, Takashi; Tanuma, akira; Yamashita, aiko; Nishimura, Tetsuo; Yasui, Hirofumi; Onitsuka, Tetsuro
- Abstract
Objective: The prognosis of patients with locally advanced squamous cell carcinoma (SCC) of the tongue is poor. Postoperative chemoradiotherapy (CRT) improves locoregional control and survival in high-risk patients. We investigated the prognostic factors for clinical T4a tongue SCC, and elucidated whether postoperative CRT has a benefit for patients with poor prognosis in terms of survival. Methods: We performed a retrospective analysis of 61 patients with stage T4a SCC of the tongue who underwent primary resection and neck dissection. Results: The median follow-up was 53.8 months. Multivariate analysis revealed a 4.26? relative risk of death for patients with the involvement of = 5 regional lymph nodes (pN = 5) compared with those with pN 0-4 (p = 0.002). In Kaplan-Meier analysis, patients with pN = 5 who received CRT had longer overall survival rates than those who did not (hazard ratio = 0.31; p = 0.041). Conclusions: pN = 5 is the most powerful prognostic factor for clinical T4a SCC of the tongue. Postoperative CRT is recommended in patients with pN = 5.
- Subjects
CANCER treatment; TONGUE tumors; CANCER; CANCER chemotherapy; MULTIVARIATE analysis; PROGNOSIS; RADIOTHERAPY; SURVIVAL; RELATIVE medical risk; KAPLAN-Meier estimator
- Publication
Oncology, 2016, Vol 91, Issue 2, p78
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000446439