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- Title
Paclitaxel-Induced Cell-Mediated Hypersensitivity Pneumonitis.
- Authors
Fujimori; Yokoyama; Kurita; Uno; Saijo
- Abstract
A 73-year-old man with mild inactive interstitial pneumonitis and non-small cell bronchogenic carcinoma developed a cell-mediated hypersensitivity pneumonitis within 15 days following a second exposure to paclitaxel. Histological features of transbronchial lung biopsy were consistent with interstitial pneumonitis. Bronchoalveolar lavage showed increased lymphocytes and eosinophils, and decreased helper/suppressor T lymphocyte ratio. Leukocyte migration inhibitory test was positive for paclitaxel. These results support the possibility that paclitaxel-induced pneumonitis is due to delayed type hypersensitivity; they also support the hypothesis of a central role of T lymphocytes in drug-induced pneumonitis.
- Subjects
PNEUMONIA; PACLITAXEL; ANTINEOPLASTIC agents; DELAYED hypersensitivity; CELLULAR immunity
- Publication
Oncology, 1998, Vol 55, Issue 4, p340
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000011873