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- Title
Prognostic Value of nm23 Protein Expression in Renal Cell Carcinomas.
- Authors
Nakagawa, Yoshinori; Tsumatani, Kenichi; Kurumatani, Norio; Cho, Masaki; Kitahori, Yoshiteru; Konishi, Noboru; Ozono, Seiichiro; Okajima, Eigoro; Hirao, Yoshihiko; Hiasa, Yoshio
- Abstract
In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as patient survival. Immunohistochemical staining of nm23-H1 and nm23-H2 was found in 68.4 and 50.5% of the cases, respectively. Significant differences in nm23-H1, but not nm23-H2 expression were noted with regard to nuclear grade and tumor size. The patients with nm23-H1-expression-negative tumors sized ≤50 mm had a significantly poorer prognosis than their positive counterparts. Multivariate analysis using the Cox proportional hazards regression model indicated that the staging in the Robson system and expression of nm23-H1 were significant and independent prognostic factors for survival. However, no significant correlation between the incidence of metastasis and expression of nm23-H1 or nm23-H2 was found. The results imply that reduced expression of nm23-H1 influences the prognosis of patients with renal cell carcinomas, but not the likelihood of metastasis. In small tumors sized ≤50 mm, reduced expression of nm23-H1 protein was suggested to be an especially strong predictor of a poor prognosis.
- Subjects
GENE expression; GENETIC regulation; RENAL cell carcinoma; RENAL cancer; CANCER
- Publication
Oncology, 1998, Vol 55, Issue 4, p370
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000011880