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- Title
Steroid-sparing effect of pimecrolimus cream 1% in children with severe atopic dermatitis.
- Authors
Zuberbier, Torsten; Heinzerling, Lucie; Bieber, Thomas; Schauer, Uwe; Klebs, Sven; Bräutigam, Matthias; Bräutigam, Matthias
- Abstract
<bold>Objective: </bold>To investigate if pimecrolimus cream 1% reduces the need for steroids in the long-term management of severe pediatric atopic dermatitis (AD).<bold>Methods: </bold>A total of 184 pediatric patients (aged 2-17 years) with a history of severe AD according to Rajka and Langeland were enrolled. Patients were randomized to treatment with pimecrolimus cream or vehicle cream for a 24-week period. Prednicarbate 0.25% was applied as rescue medication.<bold>Results: </bold>Patients on pimecrolimus required steroids on a mean of 29% of study days, compared with 35% of patients on vehicle (p = 0.1841). On the head and neck only, the respective figures were 10 versus 19% (p = 0.0009). In patients enrolled with acute severe disease (Investigator's Global Assessment > or = 4), steroids were used on 28% of the days in the pimecrolimus group compared to 45% in the control group (p = 0.0024). On the head and neck, steroids were used on 10% of study days with pimecrolimus versus 30% with vehicle (p < 0.0001).<bold>Conclusion: </bold>The results indicate that the need for topical steroids on the head and neck is reduced with pimecrolimus cream 1% in the management of severe pediatric AD according to the definition of Rajka and Langeland.
- Subjects
ATOPIC dermatitis; COMBINATION drug therapy; COMPARATIVE studies; DERMATOLOGIC agents; DOSE-effect relationship in pharmacology; TACROLIMUS; GLUCOCORTICOIDS; IMMUNOSUPPRESSIVE agents; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; OINTMENTS; RESEARCH; CUTANEOUS therapeutics; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; BLIND experiment; PREDNISOLONE
- Publication
Dermatology (10188665), 2007, Vol 215, Issue 4, p325
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000107627