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- Title
Rhein Stimulates Active Chloride Secretion in the Short-Circuited Rat Colonic Mucosa.
- Authors
Goerg, K.J.; Wanitschke, R.; Schwarz, M.; Meyer zum Büschenfelde, K.H.
- Abstract
In a short-circuited mucosa-submucosa preparation of the rat descending colon with preserved Meissner's plexus mounted as an everted sac rhein transiently increased the potential difference and short-circuit current (Isc) when administered serosally and mucosally, but serosal application was more effective. Maximal effects were obtained at rhein concentrations of 1.6 × 10-4 and 3 × 10-4 mol/l. Net chloride absorption was decreased. Indometacin (5 × 10-6 mol/l) did not inhibit the increase of Isc, but omission of calcium from the serosal side as well as tetrodoxin (2 × 10-7 mol/l) decreased it by 50 and 60%. Mechanical removal of Meissner's plexus partly blocked the effect of rhein, too. It is concluded that rhein stimulates colonic secretion by a direct action on the epithelial cells together with an indirect action via neurohumoral mechanisms. Copyright © 1988 S. Karger AG, Basel
- Publication
Pharmacology, 1988, Vol 36, Issue S1, p111
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000138429