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- Title
First enantioselective synthesis of tetrahydrochromeno[2,3-b]carbazolylacetaldehyde via trienamine catalysis and its biological activity.
- Authors
Castillo-Espinoza, Carlos E.; Pawar, Tushar Janardan; Alonso-Castro, Angel Josabad; Olivares-Romero, José Luis; Vázquez, Miguel A.; Cruz, David Cruz; Gómez, Clarisa Villegas
- Abstract
The first enantioselective synthesis of a tetrahydrochromeno[2,3-b]carbazole derivative via trienamine catalysis is presented. This molecule reduced the anxiety-like behavior in mice. On the contrary, its enantiomer showed low activity, demonstrating the importance of the stereochemisty in the corresponding cycloadduct. On the other hand, both enantiomers showed low antidepressant-like activity.
- Subjects
CATALYTIC activity; CARBAZOLE derivatives; ENAMINES; CATALYSIS; ANXIETY; ENANTIOMERS; CARBAZOLE
- Publication
Chemistry of Heterocyclic Compounds, 2022, Vol 58, Issue 6/7, p358
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-022-03098-3