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- Title
Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line.
- Authors
Y.-D. Min; C.-H. Choi; H. Bark; H.-Y. Son; H.-H. Park; S. Lee; J.-W. Park; E.-K. Park; H.-I. Shin; S.-H. Kim
- Abstract
Abstract. Objective and design: Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1. Methods: HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI). Results: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-κB and p38 mitogen-activated protein kinase. Conclusion: Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.
- Subjects
QUERCETIN; CYTOKINES; ATTENUATION (Physics); MAST cells
- Publication
Inflammation Research, 2007, Vol 56, Issue 5, p210
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-007-6172-9