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- Title
Determinants of early follicular phase gonadotrophin and estradiol concentrations in women of late reproductive age.
- Authors
Cramer, D. W.; Barbieri, R. L.; Fraer, A. R.; Harlow, B. L.
- Abstract
<bold>Background: </bold>FSH and estradiol measured during the menstrual (basal) phase of cycles predict the success of infertility treatment; but the role of these hormones as markers for ovarian reserve in normal populations needs further study.<bold>Methods and Results: </bold>From a cohort study of depressed and non-depressed women, a subset of 406 non-depressed women between the ages of 36 and 45 years with spontaneous periods were selected and their concentrations and determinants of basal hormones measured at study entry, 6 and 12 months later were described. FSH and LH increased significantly over the 12 months of observation (P <or= 0.001), but considerable variation was noted in FSH and estradiol in some women monitored over the three cycles. Concentrations often varied between a pattern of low FSH, high estradiol in one cycle and high FSH, low estradiol in another. In multivariate models focusing on the maximum observed hormone concentration, significant predictors included: increasing age (P < 0.0001), smoking (P = 0.04), and shorter cycle length (P < 0.0001) during adolescence (P < 0.0001) associated with higher FSH; increasing age (P < 0.0266) and lower body mass index (P < 0.0289) associated with higher LH; and a greater number of estimated ovulatory cycles associated with higher estradiol (P < 0.0425).<bold>Conclusions: </bold>Early reproductive landmarks, smoking, body weight, and factors that determine number of ovulatory cycles impact on ovarian/pituitary physiology in late reproductive life.
- Subjects
AGING; ANALYSIS of variance; COMPARATIVE studies; ESTRADIOL; FERTILITY; FOLLICLE-stimulating hormone; HUMAN reproduction; LUTEINIZING hormone; RESEARCH methodology; MEDICAL cooperation; MENSTRUAL cycle; OVULATION; RESEARCH; RESEARCH funding; SMOKING; TIME; EVALUATION research; BODY mass index
- Publication
Human Reproduction, 2002, Vol 17, Issue 1, p221
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/17.1.221