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- Title
AMPA-silent synapses in brain development and pathology.
- Authors
Hanse, Eric; Seth, Henrik; Riebe, Ilse
- Abstract
Synapses are constantly generated at a high rate in the developing, prepubescent brain. Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Most of these 'AMPA-silent' synapses are eliminated during the developmental period, but some are specifically selected for AMPA unsilencing by correlated pre-and postsynaptic activity as the first step in a process that leads to stabilization of the synapse. Premature, or delayed, unsilencing of AMPA-silent synapses has been implicated in neurodevelopmental disorders, and abnormal generation of AMPA-silent synapses is associated with brain trauma, addiction and neurodegenerative disorders, further highlighting the importance of AMPA-silent synapses in brain pathology.
- Subjects
NEURAL development; SYNAPSES; NERVE endings; BRAIN diseases; NEURAL transmission
- Publication
Nature Reviews Neuroscience, 2013, Vol 14, Issue 12, p839
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn3642