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- Title
Emerging roles of ATF2 and the dynamic AP1 network in cancer.
- Authors
Lopez-Bergami, Pablo; Lau, Eric; Ronai, Ze'ev
- Abstract
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.
- Subjects
TRANSCRIPTION factors; GENETIC transcription; CARCINOGENESIS; TUMOR growth; CANCER; DISEASE progression
- Publication
Nature Reviews Cancer, 2010, Vol 10, Issue 1, p65
- ISSN
1474-175X
- Publication type
research
- DOI
10.1038/nrc2681