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- Title
Calcium and cancer: targeting Ca<sup>2+</sup> transport.
- Authors
Monteith, Gregory R.; McAndrew, Damara; Faddy, Helen M.; Roberts-Thomson, Sarah J.
- Abstract
Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?
- Subjects
TARGETED drug delivery; CALCIUM in the body; CANCER; CELL death; CELL proliferation; MEDICAL research
- Publication
Nature Reviews Cancer, 2007, Vol 7, Issue 7, p519
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc2171