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- Title
有氧运动对阿尔茨海默症小鼠成年海马神经发生的影响.
- Authors
张业廷; 李垂坤; 魏翠兰; 付 燕; 张飞飞
- Abstract
BACKGROUND: Exercise improves Alzheimer’s disease, dementia, and age-related cognitive abilities. A potential mediator between exercise and these health benefits may be adult hippocampal neurogenesis. Therefore, it is of great significance to explore whether and how exercise affects the adult hippocampal neurogenesis process in Alzheimer’s disease mice. OBJECTIVE: To observe the effect of aerobic exercise on adult hippocampal neurogenesis of Alzheimer’s disease mice, and to explore whether aerobic exercise can promote their adult hippocampal neurogenesis. METHODS: Three-month-old wild-type (C57BL/6Jnju) and APP/PS1 double transgenic Alzheimer’s disease mice were randomly divided into four groups: wild control group, wild exercise group, Alzheimer’s disease control group and Alzheimer’s disease exercise group, with 20 mice in each group. The control group did not do exercise, and the exercise group did aerobic exercise for 5 months. After exercise intervention, real-time PCR, immunofluorescence and western blot assay were used to detect the expression levels of DCX, Ki67, βIII-tubulin and NeuN in the hippocampal tissue of mice in each group. RESULTS AND CONCLUSION: The expressions of DCX, βIII-tubulin and NeuN in the hippocampal dentate gyrus in the Alzheimer’s disease control group were significantly lower than those in the wild control group (P < 0.05). The expressions of DCX, Ki67, βIII-tubulin and NeuN were significantly higher in the hippocampal dentate gyrus in the Alzheimer’s disease exercise group than those in the Alzheimer’s disease control group (P < 0.05). It is indicated that longterm aerobic exercise intervention can strengthen the proliferation, migration and differentiation of neurons during adult hippocampal neurogenesis and significantly increase the number of neuronal precursor cells and new neurons in Alzheimer’s disease mice.
- Subjects
DEVELOPMENTAL neurobiology; ALZHEIMER'S disease; DENTATE gyrus; AEROBIC exercises; EXERCISE therapy; NEURONAL differentiation; PREVENTIVE medicine
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2024, Vol 28, Issue 13, p2068
- ISSN
2095-4344
- Publication type
Article
- DOI
10.12307/2024.131