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- Title
Evaluation of the antibacterial activity of Zataria multiflora Boiss., Rhus coriaria L. (sumac), Mentha piperita L., and Ocimum basilicum L. extracts on Brucella strains isolated from brucellosis patients.
- Authors
Motaharinia, Yousef; Rezaee, Mohammad Ali; Hazhir, Mohammad Saleh; Zandi, Farid; Shapouri, Reza; Hakhamaneshi, Mohammad Saied; Rashidi, Ahmad; Rahmani, Mohammad Reza
- Abstract
Aim: Since brucellosis has been called a chronic illness and treatment of patients infected with this bacterium has not been successful, the present study aimed to evaluate the effects of several medicinal plant extracts on clinical Brucella strains. Materials and methods: First, Brucella strains were isolated from brucellosis patients. Then an antibiotic resistance assay was performed for these strains, while the antibacterial activity of the above-mentioned extracts was evaluated. Results: After performing accurate evaluations, the obtained results showed that all of the isolated Brucella strains were sensitive to tetracycline, doxycycline, and gentamicin, and the rates of antibiotic resistance to rifampin and streptomycin were 83.3% and 11.1%, respectively. The mean zone of growth inhibition for Zataria multiflora Boiss. was ≥28.77 mm, Rhus coriaria L. (sumac) was 22.55 mm, Mentha piperita L. was ≥7.5 mm, and the gentamicin disk was ≥30 mm. The mean minimum inhibitory concentration (MIC) for Z. multiflora was 1237 µg/mL, and it was 3255.2 µg/mL for sumac, and 5642 µg/mL for M. piperita L. The minimum bactericidal concentration (MBC) rate for these herbs was 5900 µg/mL, 9027 µg/mL, and 12152 µg/mL, respectively. Furthermore, no anti-Brucella activity was observed for Ocimum basilicum L. Conclusion: The results obtained in this study prove that Z. multiflora extracts show high anti-Brucella activity and it can be used for better treatment of brucellosis.
- Subjects
ANTIBACTERIAL agents; RHUS; PEPPERMINT; BASIL; BRUCELLA; BRUCELLOSIS; PLANT extracts
- Publication
Turkish Journal of Medical Sciences, 2012, Vol 42, Issue 5, p816
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-1106-39