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- Title
Angiotensin II Receptor mRNA Expression and Vasoconstriction in Human Coronary Arteries: Effects of Heart Failure and Age.
- Authors
Wackenfors, Angelica; Pantev, Emil; Emilson, Malin; Edvinsson, Lars; Malmsj, Malin
- Abstract
Angiotensin II is a potent vasoconstrictor that is implicated in the pathogenesis of hypertension, heart failure and atherosclerosis. In the present study, angiotensin II receptor mRNA expression levels were quantified by real-time polymerase chain reaction and the vasocontractile responses to angiotensin II were characterised byin vitropharmacology in endothelium-denuded human coronary arteries. Angiotensin II type 1 (AT1) and type 2 (AT2) receptor mRNA expression levels were significantly down-regulated in arteries from patients with heart failure as compared to controls. The angiotensin II-induced vasoconstriction diminished with increasing age in patients with heart failure (r2=0.31, P<0.05). Also, the AT1 receptor mRNA expression levels decreased with increasing age in patients with heart failure (r2=0.74, P<0.05), while no such correlation could be shown in the control group (r2=0.04, P=n.s.). The AT2 receptor mRNA expression levels did not correlate with age in patients with heart failure or controls. In conclusion, the diminished angiotensin II vasoconstriction with age in heart failure patients is most likely due to a lower density of AT1 receptors and may result from a longer period of exposure to heart failure in older patients.
- Subjects
ANGIOTENSIN II; VASOCONSTRICTORS; CARDIOVASCULAR agents; MESSENGER RNA; GENE expression; TOXICOLOGY; PHARMACOLOGY; MEDICAL sciences
- Publication
Basic & Clinical Pharmacology & Toxicology, 2004, Vol 95, Issue 6, p266
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2004.t01-1-pto950504.x