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- Title
精神分裂症患者动态功能连接和 效应连接的功能磁共振成像研究.
- Authors
刘文娟; 杨伟亮; 叶师敏; 牛慧明; 金毅琼; 李刚; 王刚平; 候宁; 李洁
- Abstract
Objective: To explore the characteristics of brain dynamic activity in patients with schizophrenia by using functional magnetic resonance imaging (fMRI). Methods: Forty-three patients with schizophrenia and 31 normal controls were recruited and under fMRI scanning. The Positive and Negative Symptom Scale (PANS) was used to assess the severity of clinical symptoms. The DPABI software were used to compute dReHo and dFC. Granger causality analysis was used to calculate the effective connectivity between the significant brain regions of dReHo and the whole brain. Two sample t-test was performed to compare the difference of dReHo and dFC between patients with schizophrenia and normal controls. Results: The dReHo of left postcentral gyrus (LPG) (P < 0. 01, cluster-level FWE corrected) in patients with schizophrenia was decreased. The Dfc was increased between left postcentral and left middle frontal gyrus, left superior medial frontal gyrus, right calcarine, left medial cingulum gyrus, right supplementary motor area (P<0.01, uncorrected). Compared with normal controls, patients with schizophrenia showed decreased effective connectivity from LPG to right putamen. Conclusion: It suggests that the abnormal functional activity of the postcentral gyrus might contribute to the neural physiopathology in patients with schizophrenia.
- Publication
Chinese Mental Health Journal / Zhongguo Xinli Weisheng Zazhi, 2024, Vol 38, Issue 7, p585
- ISSN
1000-6729
- Publication type
Article
- DOI
10.3969/j.issn.1000-6729.2024.07.006